Benedetta Pettorini


Consultant Paediatric Neurosurgeon AHCH

Benedetta Pettorini qualified as a doctor (MD) from the Catholic University of Rome, in Italy, in 2002. Her basic surgical and neurosurgical training took place in Rome. Thereafter her advanced Paediatric Neurosurgical training was completed in United Kingdom with a Fellowship in Paediatric Neurosurgery in Birmingham Children’s Hospital and in Great Ormond Street Hospital, London.

Miss Pettorini is a full time Consultant Paediatric Neurosurgeon at Alder Hey Children’s NHS Foundation Trust since 2011, one of the busiest paediatric hospitals in Europe.


  • MD, European Specialty Qualification in Neurosurgery. Qualified in 2002.
  • Neurosurgical training at the Catholic University of Rome, Italy. Qualified in 2007.
  • Paediatric Neurosurgery fellowships at the Birmingham Children’s Hospital and Great Ormond Street Hospital in London.

Department and Specialties

Consultant Neurosurgeon at Alder Hey Children’s’ NHS Foundation, Liverpool, UK.

Miss Pettorini started in pediatric Neurosurgery in Alder Hey Hospital 01 June 2011 following her Clinical fellowship in Great Ormond Street Hospital in London from December 2010 – May 2011. She has trained in several countries during her training.

Chief of Operative Care at Alder Hey Children’s’ NHS Foundation, Liverpool, UK.

Miss Pettorini has recently accepted the role of Chief of Operative Care here at Alder Hey commencing August 2016. Miss Pettorini is in charge of the Best in Operative Care Group which is aiming to improve utilization, productivity and safety of the theatres department at Alder Hey.


Clinical Interests

Miss Pettorini’s areas of particular interest are all areas of Paediatric Neurosurgery including hydrocephalus (shunts and basic and complex endoscopy), Chiari malformation, spinal dysraphisms, neuro-oncology (brain and spinal tumours), spasticity treatment (Baclofen pump, selective dorsal rhizotomy, peripheral neurectomy), neurosurgery in prematurity.

She is part of the multidisciplinary neuro-oncology team and multidisciplinary spasticity team at Alder Hey Children’s NHS Foundation Trust.

She runs an outreach clinic in Stoke on Trent providing paediatric neurosurgery service for the area, and an outreach clinic in Belfast providing selective dorsal rhizotomy service for Northern Ireland.

Current Memberships

SBNS – Society of British Neurosurgeons

ISPNO – International Society Pediatric Neuro-Oncology

ISPN – International Society Pediatric Neurosurgery

BPNG – British Paediatric Neurosurgery Group

Core member of neurosurgery and craniopharyngioma groups of SIOP-E (European

Society Paediatric Neuro-Oncology)

Additional information

Miss Pettorini is in charge of surgical site infection surveillance and prevention at Alder Hey. Since a SSI bundle was introduced in neurosurgery, rates of infection in the Neurosurgical department has significantly reduced. She is in charge of recording incidents of surgical site infection (SSI), to help to improve surgical practice and prevent infections.

Having introduced Selective Dorsal Rhizotomy (SDR) as a new treatment for spasticity in the region in 2012, Miss Pettorini leads the service which had been commissioned in 2014 as one of the five units to provide a commissioned service by NHS England. The spasticity service has been awarded with the “Investing in Children’s Service” national award.

Miss Pettorini has received a grant from Children with Cancer UK for research in Craniopharyngioma in the context of an international multicentre consortium.

Miss Pettorini is involved in regular teaching with trainee doctors and medical students providing regular support and guidance.

She has been part of the local organizing committee of the ISPNO meeting hold in Liverpool in 2016 and she is part of the organizing committee and faculty of the Paediatric Neurosurgery Masterclass since 2012.

She has been awarded Top Chief Investigator by NIHR in 2015.

Miss Pettorini has presented and been invited to several national and international meeting and has published several publications.


1: Ellenbogen JR, Waqar M, Pettorini B. Management of post-haemorrhagic

hydrocephalus in premature infants. J Clin Neurosci 31:30-4, 2016

2: Isaac E, Lang J, Sinha A, Pettorini B. Neurofibroma of the cervical spine in

infants. Childs Nerv Syst 32(6):1023-4, 2016

3: Narenthiran G, Parks C, Pettorini B. Management of Chiari I malformation in

children: effectiveness of intra-operative ultrasound for tailoring foramen

magnum decompression. Childs Nerv Syst 31(8):1371-6. 2015

.4: Kitchen WJ, Pizer B, Pettorini B, Husband D, Mallucci C, Jenkinson MD.

Paediatric intracranial anaplastic ependymoma: the role of multiple surgical

resections for disease relapse in maintaining quality of life and prolonged

survival. Pediatr Neurosurg 50(2):68-72 2015

5: del Bufalo F, Carai A, Figà-Talamanca L, Pettorini B, Mallucci C, Giangaspero

F, Antonelli M, Badiali M, Moi L, Bianco G, Cacchione A, Locatelli F, Ferretti E,

Mastronuzzi A. Response of recurrent BRAFV600E mutated ganglioglioma to

Vemurafenib as single agent. J Transl Med 19;12:356, 2014

6: Avula S, Kumar R, Pizer B, Pettorini B, Abernethy L, Garlick D, Mallucci C.

Diffusion abnormalities on intraoperative magnetic resonance imaging as an early

predictor for the risk of posterior fossa syndrome. Neuro Oncol 17(4):614-22, 2015

7: Waqar M, Ellenbogen JR, Kumar R, Sneade C, Zebian B, Williams D, Pettorini BL.

Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable

baclofen delivery system in severely cachectic patients. J Neurosurg Pediatr

14(4):409-13, 2014

8: Millward CP, Perez da Rosa S, Williams D, Kokai G, Byrne A, Pettorini B.

Foreign body granuloma secondary to ventriculo-peritoneal shunt: a rare scenario

with a new insight. Pediatr Neurosurg 49(4):236-9, 2013

9: Goodden J, Pizer B, Pettorini B, Williams D, Blair J, Didi M, Thorp N,

Mallucci C. The role of surgery in optic pathway/hypothalamic gliomas in

children. J Neurosurg Pediatr 13(1):1-12, 2014

10: Jumani DB, Littlewood R, Iyer A, Fellows G, Healey A, Abernethy L, Spinty S,

Sarginson R, Pettorini B. Spontaneous spinal epidural haematoma mimicking

meningitis in a 2-year-old child–a case report and literature review. Childs

Nerv Syst 29(10):1795-8, 2013

11: Avula S, Pettorini B, Abernethy L, Pizer B, Williams D, Mallucci C. High

field strength magnetic resonance imaging in paediatric brain tumour surgery–its

role in prevention of early repeat resections. Childs Nerv Syst 29(10):1843-50, 2013

12: Neligan A, Haliasos N, Pettorini B, Harkness WF, Solomon JK. A survey of

adult and pediatric epilepsy surgery in the United Kingdom. Epilepsia 54(5):e62-5, 2013

13: Mangiola A, Saulnier N, De Bonis P, Orteschi D, Sica G, Lama G, Pettorini BL,

Sabatino G, Zollino M, Lauriola L, Colabianchi A, Proietti G, Kovacs G, Maira G,

Anile C. Gene expression profile of glioblastoma peritumoral tissue: an ex vivo

study. PLoS One 8(3):e57145, 2013

14: Fayeye O, Pettorini BL, Smith M, Williams H, Rodrigues D, Kay A.

Meningococcal encephalitis associated with cerebellar tonsillar herniation and

acute cervicomedullary injury. Br J Neurosurg. 27(4):513-5, 2013

15: Keh YS, Abernethy L, Pettorini B. Association between Noonan syndrome and

Chiari I malformation: a case-based update. Childs Nerv Syst 29(5):749-52, 2012

16: Pettorini BL, Al-Mahfoud R, Jenkinson MD, Avula S, Pizer B, Mallucci C.

Surgical pathway and management of pineal region tumours in children. Childs Nerv

Syst Mar;29(3):433-9, 2013

17: Mallucci C, Pizer B, Blair J, Didi M, Doss A, Upadrasta S, Newman W, Avula S,

Pettorini B. Management of craniopharyngioma: the Liverpool experience following

the introduction of the CCLG guidelines. Introducing a new risk assessment

grading system. Childs Nerv Syst 28(8):1181-92, 2012

18: De Bonis P, Albanese A, Lofrese G, de Waure C, Mangiola A, Pettorini BL,

Pompucci A, Balducci M, Fiorentino A, Lauriola L, Anile C, Maira G. Postoperative

infection may influence survival in patients with glioblastoma: simply a myth?

Neurosurgery 69(4):864-8; discussion 868-9, 2011

19: Dhamija B, Pettorini BL, Solanki G. Endoscopic third ventriculostomy for the

treatment of osteopetrosis-related hydrocephalus: a case-based update. Childs

Nerv Syst 27(11):1861-5, 2011

20: Pettorini BL, Gao A, Rodrigues D. Acute deterioration of a Chiari I

malformation: an uncommon neurosurgical emergency. Childs Nerv Syst

27(6):857-60, 2011

21: Massimi L, Pravatà E, Tamburrini G, Gaudino S, Pettorini B, Novegno F,

Colosimo C Jr, Di Rocco C. Endoscopic third ventriculostomy for the management of

Chiari I and related hydrocephalus: outcome and pathogenetic implications.

Neurosurgery 68(4):950-6, 2011

22: Pettorini B, Abbas N, Magdum S. Amniotic band syndrome with tethering of the

spinal cord: a case-based update. Childs Nerv Syst 27(2):211-4, 2011

23: Pettorini BL, Inzitari R, Massimi L, Tamburrini G, Caldarelli M, Fanali C,

Cabras T, Messana I, Castagnola M, Di Rocco C. The role of inflammation in the

genesis of the cystic component of craniopharyngiomas. Childs Nerv Syst

26(12):1779-84, 2010

24: Di Rocco C, Chieffo D, Pettorini BL, Massimi L, Caldarelli M, Tamburrini G.

Preoperative and postoperative neurological, neuropsychological and behavioral

impairment in children with posterior cranial fossa astrocytomas and

medulloblastomas: the role of the tumor and the impact of the surgical treatment.

Childs Nerv Syst 26(9):1173-88, 2010

25: Fayeye O, Pettorini BL, Foster K, Rodrigues D. Mesencephalic enlarged

Virchow-Robin spaces in a 6-year-old boy: a case-based update. Childs Nerv Syst

26(9):1155-60, 2010

26: Cavalheiro S, Di Rocco C, Valenzuela S, Dastoli PA, Tamburrini G, Massimi L,

Nicacio JM, Faquini IV, Ierardi DF, Silva NS, Pettorini BL, Toledo SR.

Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a

multicenter preliminary study with 60 cases. Neurosurg Focus 28(4):E12, 2010

27: Pettorini BL, Frassanito P, Caldarelli M, Tamburrini G, Massimi L, Di Rocco

  1. Molecular pathogenesis of craniopharyngioma: switching from a surgical

approach to a biological one. Neurosurg Focus 28(4):E1, 2010

28: Pettorini BL, Tamburrini G, Massimi L, Paternoster G, Caldarelli M, Di Rocco

  1. The use of a reconstituted collagen foil dura mater substitute in paediatric

neurosurgical procedures–experience in 47 patients. Br J Neurosurg 24(1):51-4,


29: Cianfoni A, da Graca Morais Martin M, Luigetti M, Pettorini BL, Hesselink JR.

Spontaneous regression of a midbrain lesion in a patient with chronic

transtentorial herniation: is it a pre-syrinx? J Neurol 257(5):848-50, 2010

30: Nardi P, Cabezas D, Rea G, Pettorini BL. Aperius PercLID stand alone

interspinous system for the treatment of degenerative lumbar stenosis: experience

on 152 cases. J Spinal Disord Tech 23(3):203-7, 2010

31: Pettorini BL, Oesman C, Magdum S. New presenting symptoms of Chiari I

malformation: report of two cases. Childs Nerv Syst 26(3):399-402, 2010

32: Pettorini BL, Tamburrini G, Massimi L, Caldarelli M, Di Rocco C. Endoscopic

transventricular positioning of intracystic catheter for treatment of

craniopharyngioma. Technical note. J Neurosurg Pediatr 4(3):245-8, 2009

33: Pettorini BL, Novegno F, Cianfoni A, Massimi L, De Bonis P, Esposito G,

Caldarelli M, Tamburrini G, Di Rocco C, Giangaspero F, Lauriola L. 5-year-old boy

with a clival mass. Brain Pathol 19(3):523-6, 2009

34: Tamburrini G, D’Ercole M, Pettorini BL, Caldarelli M, Massimi L, Di Rocco C.

Survival following treatment for intracranial ependymoma: a review. Childs Nerv

Syst 25(10):1303-12, 2009

35: Massimi L, De Bonis P, Esposito G, Novegno F, Pettorini B, Tamburrini G,

Caldarelli M, Di Rocco C. Vertex scalp mass as presenting sign of a complex

intracranial vascular malformation. J Neurosurg Pediatr 3(4):307-10, 2009

36: Pettorini BL, Narducci A, de Carlo A, Abet F, Caldarelli M, Massimi L,

Tamburrini G, Di Rocco C. Thyroid neoplasm after central nervous system

irradiation for medulloblastoma in childhood: report of two cases. Childs Nerv

Syst 25(5):631-4, 2009

37: Tamburrini G, Pettorini BL, Massimi L, Caldarelli M, Di Rocco C. Endoscopic

third ventriculostomy: the best option in the treatment of persistent

hydrocephalus after posterior cranial fossa tumour removal? Childs Nerv Syst

24(12):1405-12, 2008

38: Novegno F, Caldarelli M, Massa A, Chieffo D, Massimi L, Pettorini B,

Tamburrini G, Di Rocco C. The natural history of the Chiari Type I anomaly. J

Neurosurg Pediatr 2(3):179-87, 2008

39: Pettorini BL, Frassanito P, Tamburrini G, Massimi L, Caldarelli M, Di Rocco

  1. Retrieval of ventricular catheter with the aid of endoscopy: technical note. J

Neurosurg Pediatr 2(1):71-4, 2008

40: Pettorini BL, Park YS, Caldarelli M, Massimi L, Tamburrini G, Di Rocco C.

Radiation-induced brain tumours after central nervous system irradiation in

childhood: a review. Childs Nerv Syst 24(7):793-805, 2008

41: Pettorini BL, Tamburrini G, Montano N, Massimi L, Caldarelli M, Fasano T,

Paternoster G, Di Rocco C. CSF otorrhea after anterior temporal craniotomy due to

hyperpneumatization of the temporal bone. Pediatr Neurosurg 44(2):176-7, 2008

42: Frassanito P, Pettorini B. Pink and blue: the color of gender. Childs Nerv

Syst 24(8):881-2, 2008

43: Pompucci A, De Bonis P, Pettorini B, Petrella G, Di Chirico A, Anile C.

Decompressive craniectomy for traumatic brain injury: patient age and outcome. J

Neurotrauma 24(7):1182-8, 2007

44: Pettorini BL, Massimi L, Cianfoni A, Paternoster G, Tamburini G, Di Rocco C.

Thoracic lipomeningocele associated with diastematomyelia, tethered spinal cord,

and hydrocephalus. Case report. J Neurosurg 106(5 Suppl):394-7, 2007

45: Pettorini BL, Tamburrini G. Two hundred years of endoscopic surgery: from

Philipp Bozzini’s cystoscope to paediatric endoscopic neurosurgery. Childs Nerv

Syst 23(7):723-4, 2007

46: Mangiola A, Maira G, De Bonis P, Porso M, Pettorini B, Sabatino G, Anile C.

Glioblastoma multiforme in the elderly: a therapeutic challenge. J Neurooncol

76(2):159-63, 2006